Short answer: if it's open, the sign applies to you, and the answer is yes. Longer answer: here's exactly who must stop, what happens inside, how the bypass transponders earn their subscription, and why the goal of your career is making every weigh station visit profoundly boring.
Rules are state law, so details vary, but the working reality: commercial vehicles over 10,000 lbs GVWR must stop at open stations in most states (some set the line higher, some pull in anything with a USDOT number). The signs at each station say who's required — and the correct way to read an ambiguous sign at 65 mph is "that means me." Closed station, lights off, "CLOSED" on the board? Keep rolling; that part really is that simple.
The station notices — that's their whole job. Expect some combination of a fine (a few hundred dollars, state-dependent), a radio call to an officer down the road who will bring you back or write you up on the shoulder, and — the expensive part — an invitation to a much more thorough inspection than the one you skipped. Nobody who bypasses a scale gets the quick wave-through afterward. The two minutes you "saved" have a way of becoming ninety.
PrePass and Drivewyze let enrolled trucks with decent carrier scores get a green light to skip the station at highway speed — the state pre-screens you electronically and most stops never happen. For anyone running serious miles through scale-dense corridors, the subscription typically pays for itself in saved time and fuel within weeks. Two honest caveats: a bypass is a maybe, not a right — you can still get red-lighted in, so don't treat the transponder as a stealth device — and your bypass rate tracks your carrier's safety score, which is one more reason clean inspections compound.
Roadmark's map shows every station on your route in advance — because the difference between a checkpoint and an ambush is whether you knew it was coming.
If it's open and the signage applies to your vehicle class, yes — state rules vary in detail, but blowing past an open scale you were required to enter is a stop-and-fine offense.
PrePass and Drivewyze can grant bypasses when your carrier's scores qualify, but the green light is per-site and per-pass — the transponder decides, not habit.
Expect to be chased down or flagged, fined, and inspected with extra enthusiasm. Cheaper to lose ten minutes than to meet the inspector angry.